Application of the four-component Ugi condensation for the preparation of sulfated glycoconjugate libraries

Ligong Liu; Cai Ping Li; Siska Cochran; Vito Ferro

doi:10.1016/j.bmcl.2004.02.017

Application of the four-component Ugi condensation for the preparation of sulfated glycoconjugate libraries

Bioorg Med Chem Lett. 2004 May 3;14(9):2221-6. doi: 10.1016/j.bmcl.2004.02.017.

Authors

Ligong Liu¹, Cai Ping Li, Siska Cochran, Vito Ferro

Affiliation

¹ Drug Design Group, Progen Industries Ltd, 2806 Ipswich Rd, Darra, Qld 4076, Australia.

PMID: 15081013
DOI: 10.1016/j.bmcl.2004.02.017

Abstract

A focused library of novel, sulfated glycoconjugates was synthesized by utilizing carbohydrate-derived blocks in the four-component Ugi condensation. Library members comprise a sulfated monosaccharide linked by various spacers to either an aromatic or monosulfated moiety, or a second sulfated monosaccharide. The affinities of these heparan sulfate (HS) mimetics for the HS-binding fibroblast growth factors FGF-1 and FGF-2 were measured via a surface plasmon resonance solution affinity assay.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Fibroblast Growth Factor 1 / chemistry
Fibroblast Growth Factor 2 / chemistry
Glycoconjugates / chemistry*
Molecular Mimicry
Sulfates / chemistry*
Surface Plasmon Resonance

Substances

Glycoconjugates
Sulfates
Fibroblast Growth Factor 2
Fibroblast Growth Factor 1